Allan Maxam
Allan Maxam | |
|---|---|
| Born | October 28, 1942 |
| Known for | Maxam–Gilbert sequencing |
| Scientific career | |
| Fields | Molecular genetics |
| Workplaces | Harvard University |
| Walter Gilbert | |
Allan Maxam (born October 28, 1942) is an American geneticist and one of the pioneers of molecular genetics. He co-developed the Maxam–Gilbert DNA sequencing method in 1976–1977 at Harvard University while working as a student in the laboratory of Walter Gilbert.[1][2]
Maxam–Gilbert sequencing combined chemicals that cut DNA only at specific bases with radioactive labeling and polyacrylamide gel electrophoresis to determine the sequence of long DNA segments.[3]
Their 1977 paper "A new method for sequencing DNA" was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society for 2017. It was presented to the Department of Molecular & Cellular Biology at Harvard University.[1][4]
See also
[edit]References
[edit]- 1 2 Maxam, A M; Gilbert, W (1977), "A new method for sequencing DNA.", Proc. Natl. Acad. Sci. U.S.A., vol. 74, no. 2 (published February 1977), pp. 560–4, Bibcode:1977PNAS...74..560M, doi:10.1073/pnas.74.2.560, PMC 392330, PMID 265521
- ↑ DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980
- ↑ Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560
- ↑ "Citations for Chemical Breakthrough Awards 2017 Awardees". Division of the History of Chemistry. Retrieved March 12, 2018.
Further reading
[edit]- Gilbert, Walter and Maxam. Allan, The Nucleotide Sequence of the Lac Operator, Proc. Natl. Acad. Sci. USA 70, 3581-3584 (1973).
- Maxam AM, Tizard R, Skryabin KG, Gilbert W, Promoter region for yeast 5S ribosomal RNA, Nature. 1977 June 16;267(5612):643-5
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