ใ็ฎ่ใๆฉๆ็ฎ่ๆๅนณไธ็ฎ็ใฎๅ็บ็
Early invasive squamous cell carcinoma recurrence rates: A study examining surgical margins, tumor surface diameter, invasion depth, and grade of differentiation in 1296 cases over 9 years
J Cutan Pathol. 2019 Feb;46(2):111-116.
็ฎ่ใฎๆๅนณไธ็ฎ็ใฏๅคๅฝฉใงใใใใใใใ็บ็้จไฝใๅคๅฝฉใงใใใๅใ็ฎ่ใงใใใฐใใฐๅ ดๆใซใใๆง่ณชใ็ฐใชใใ่งฃๅๅญฆ็้จไฝใใใจใชใใใใในใใผใธใณใฐใๅฐ้ฃใงใใใใใฎใใใAJCC ็ฌฌ๏ผ็ใงใฏ็ฎ่ๆๅนณไธ็ฎ็ใฎในใใผใธใณใฐใฏๅ้คใใใใใชใใUICC ็ฌฌ๏ผ็ใงใฏๆฎใฃใฆใใใใใฎ่ซๆใงใฏๅ จ่บซใฎ็ฎ่ๆๅนณไธ็ฎ็ใ็นใซใๆฉๆ็ใใซใคใใฆๅ็บๅ ๅญใๆค่จใใฆใใใ
ใชใใ็ฎ่ใซ้ขใใฆใๆๆฃ็ดฐ่็ใใฎๅ็งฐใๅฅฝใพใใๅพๅใใใฃใใใๅพใ ใซใๆๅนณไธ็ฎ็ใใฎๆนใไธ่ฌๅใใคใคใใใ
Abstract
Background: Invasive squamous cell carcinoma (SCC) is typically treated by surgical excision.
Methods: Consecutive SCC excisions were reviewed prospectively in a single Australian center from 2009 to 2017. Cases were examined for recurrence by histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation, and anatomic site.
Results: Over 9 years, 1296 cases were collected. By grade of differentiation maximum average microscopic surface diameters ranged from 8.0 to 9.6 mm and maximum average depths from 1.3 to 2.5 mm. Minimum average histopathologic margins for well, moderate, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Recurrence occurred in 1.7% of well (n = 18/1084), 1.8% moderate (n = 3/165) and 6.4% in poorly differentiated (n = 3/47) SCC. No recurrence occurred beyond a histopathologic margin of 3.5 mm for well and 2.5 mm for moderately differentiated SCC. Highest recurrence for well-differentiated SCC by anatomic site was the lip (7.0%) then ear (4.6%).
Conclusion: We found a recurrence rate of 1.0% for histopathologic margins of 1.5 mm with early well-differentiated SCC. The grade of differentiation and anatomic site had a larger influence on recurrence rates compared to the histopathologic margins. Poorly differentiated SCC and ear or lip sites require wider surgical margins.
Keywords: grade of differentiation; invasion depth; invasive squamous cell carcinoma; recurrence rates; surgical margins.
ใชใใใใใชใใซๅ็พๆงใ้ซใใใชใฉๅ้กใซใชใใใใชๅ ๅฎนใงใใใใ1296 ไพใฎๆค่จใฏๅ็ดใซๅใใจๆใใๅใๅบใใซ้ขใใฆใฏ 3 mm ๅใงๅ จๅฒใจๆฌๆไธญใซ่จ่ผใใใฆใใใใ่จๆธฌใฏ 0.1 mm ๅไฝใง่กใใใฆใใใ่ณชใฏๆ ไฟใใใฆใใใใจๆใใ
ๅๅๅบฆใฎ่ฉไพกใฎๅ็พๆงใๅ้กใจใชใใจๆใใ ใใใใๅๅๅบฆใซใคใใฆใฏใไฝๅๅใใงใใใใจใ้่ฆใชใฎใงใใใฎ็นใงใฏๅใใใใใใ้ซๅๅใงใใผใธใณ็ขบไฟใใใฆใใใฐๅ็บ็ใฏไฝใใจใชใฃใฆใใใใ้ซๅๅใจไธญๅๅใฎๅข็ใฏๅฎ้ใฎ่จบๆญใงใฏๅ็พๆงใไฝใใใงใใใ
ใSANOTIC SUMMARYใ
๏ผ๏ผๅๅๅบฆใ้่ฆ๏ผไฝๅๅใฏ้ซใปไธญๅๅใใใๅ็บ็ใ้ซใ
๏ผ๏ผๅ ดๆใ้่ฆ๏ผ่ณใจๅฃๅใฏๅ็บ็ใ้ซใโใใผใธใณ็ขบไฟใ้่ฆ
๏ผ๏ผ้ซๅๅใซ้ขใใฆใฏ 1.5 mm ใฎใใผใธใณใ็ขบไฟใใใใฐๅ็บ็ใ 1.0%ใซๆใใใใ
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