B3GAT1

B3GAT1
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	1V82, 1V83, 1V84
Identifikatori
Alijasi	B3GAT1
Spoljašnji ID	OMIM: 151290 MGI: 1924148 HomoloGene: 49551 GeneCards: B3GAT1
EC number	2.4.1.135
Genska lokacija (miš)
Hr.	Chromosome 9 (mouse)
Kraj	26,674,397 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • metal ion binding; • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; • UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;
Cellular component	• саставни део мембране; • Голџијев апарат; • мембрана; • ванћелијска област; • ендоплазматични ретикулум; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • Golgi membrane;
Biological process	• glycosaminoglycan metabolic process; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • chondroitin sulfate proteoglycan biosynthetic process; • chondroitin sulfate metabolic process; • Метаболизам угљених хидрата; • cellular response to hypoxia;
	Sources:Amigo / QuickGO
Ortolozi
	27087
	76898
	ENSG00000109956
	ENSMUSG00000045994
	Q9P2W7
	Q9CW73
	NM_018644; NM_054025; NM_001367973
	NM_029792; NM_001310766
	NP_061114; NP_473366; NP_001354902
	NP_001297695; NP_084068
	Wikidata
View/Edit Human	View/Edit Mouse

3-beta-glukuronoziltransferaza 1 (B3GAT1) je enzim koji je kod ljudi kodiran genom B3GAT1, čija enzimska aktivnost stvara CD57 epitop na drugim proteinima na površini ćelije.^[4] U imunologiji, antigen CD57 (CD označava klaster diferencijacije) je takođe poznat kao HNK1 (ljudski prirodni ubica-1) ili LEU7. Izražava se kao epitop ugljenih hidrata koji sadrži sulfoglukuronilni ostatak u nekoliko adhezionih molekula nervnog sistema.^[5]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000045994 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)”. Архивирано из оригинала 15. 10. 2023. г. Приступљено 12. 10. 2023.
^ Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (април 2000). „Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope”. Genomics. 65 (2): 166—173. PMID 10783264. doi:10.1006/geno.2000.6152.

Literatura

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (април 1996). „A "double adaptor" method for improved shotgun library construction”. Analytical Biochemistry. 236 (1): 107—113. PMID 8619474. doi:10.1006/abio.1996.0138.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (април 1997). „Large-scale concatenation cDNA sequencing”. Genome Research. 7 (4): 353—358. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Tone Y, Kitagawa H, Imiya K, Oka S, Kawasaki T, Sugahara K (октобар 1999). „Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. FEBS Letters. 459 (3): 415—420. PMID 10526176. S2CID 7878952. doi:10.1016/S0014-5793(99)01287-9 .
Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (април 2000). „Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope”. Genomics. 65 (2): 166—173. PMID 10783264. doi:10.1006/geno.2000.6152.
Pedersen LC, Tsuchida K, Kitagawa H, Sugahara K, Darden TA, Negishi M (новембар 2000). „Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I”. The Journal of Biological Chemistry. 275 (44): 34580—34585. PMID 10946001. doi:10.1074/jbc.M007399200 .
Cebo C, Durier V, Lagant P, Maes E, Florea D, Lefebvre T, et al. (април 2002). „Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands”. The Journal of Biological Chemistry. 277 (14): 12246—12252. PMID 11788581. doi:10.1074/jbc.M106816200 .
Ouzzine M, Gulberti S, Levoin N, Netter P, Magdalou J, Fournel-Gigleux S (јул 2002). „The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues”. The Journal of Biological Chemistry. 277 (28): 25439—25445. PMID 11986319. doi:10.1074/jbc.M201912200 .
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. (април 2003). „Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells”. Blood. 101 (7): 2711—2720. PMID 12433688. doi:10.1182/blood-2002-07-2103 .
Jirásek T, Hozák P, Mandys V (2003). „Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal carcinoids: immunohistochemical and confocal laser scanning microscopy study”. Neoplasma. 50 (1): 1—7. PMID 12687271.
Jeffries AR, Mungall AJ, Dawson E, Halls K, Langford CF, Murray RM, et al. (јул 2003). „beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation”. Molecular Psychiatry. 8 (7): 654—663. PMID 12874601. doi:10.1038/sj.mp.4001382 .
Chochi K, Ichikura T, Majima T, Kawabata T, Matsumoto A, Sugasawa H, et al. (2004). „The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer”. Oncology Reports. 10 (5): 1443—1448. PMID 12883721. doi:10.3892/or.10.5.1443.
Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajihara Y, et al. (мај 2004). „Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1”. The Journal of Biological Chemistry. 279 (21): 22693—22703. PMID 14993226. doi:10.1074/jbc.M400622200 .
Matsubara K, Yura K, Hirata T, Nigami H, Harigaya H, Nozaki H, et al. (2005). „Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report”. Pediatric Hematology and Oncology. 21 (7): 677—682. PMID 15626024. S2CID 41086927. doi:10.1080/08880010490501105.
Ibegbu CC, Xu YX, Harris W, Maggio D, Miller JD, Kourtis AP (мај 2005). „Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57”. Journal of Immunology. 174 (10): 6088—6094. PMID 15879103. doi:10.4049/jimmunol.174.10.6088 .
Assouti M, Vynios DH, Anagnostides ST, Papadopoulos G, Georgakopoulos CD, Gartaganis SP (јануар 2006). „Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome”. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (1): 54—58. PMID 16257185. doi:10.1016/j.bbadis.2005.09.005 .
Barré L, Venkatesan N, Magdalou J, Netter P, Fournel-Gigleux S, Ouzzine M (август 2006). „Evidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesis”. FASEB Journal. 20 (10): 1692—1694. PMID 16807373. S2CID 16549210. doi:10.1096/fj.05-5073fje.
Sada-Ovalle I, Torre-Bouscoulet L, Valdez-Vázquez R, Martínez-Cairo S, Zenteno E, Lascurain R (децембар 2006). „Characterization of a cytotoxic CD57+ T cell subset from patients with pulmonary tuberculosis”. Clinical Immunology. 121 (3): 314—323. PMID 17035093. doi:10.1016/j.clim.2006.08.011.

Spoljašnje veze

CD57+Antigen на US National Library of Medicine Medical Subject Headings (MeSH)
Human B3GAT1 genome location and B3GAT1 gene details page in the UCSC Genome Browser.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000045994 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] „Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)”. Архивирано из оригинала 15. 10. 2023. г. Приступљено 12. 10. 2023.

[pmid10783264-5] Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (април 2000). „Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope”. Genomics. 65 (2): 166—173. PMID 10783264. doi:10.1006/geno.2000.6152.

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п р у Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350