Glutamyl aminopeptidase

ENPEP
Identifiers
Aliases	ENPEP, APA, CD249, gp160, glutamyl aminopeptidase
External IDs	OMIM: 138297; MGI: 106645; GeneCards: ENPEP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KXD, 4KXA, 4KXB, 4KX7, 4KX9, 4KXC, 4KX8
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	110,565,285 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,126,369 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; glomerulus; ; metanephric glomerulus; ; mucosa of ileum; ; kidney tubule; ; human kidney; ; duodenum; ; gonad; ; liver; ; placenta;
	Top expressed in
	vestibular sensory epithelium; ; stria vascularis; ; ileum; ; utricle; ; jejunum; ; migratory enteric neural crest cell; ; renal corpuscle; ; intestinal villus; ; epithelium of small intestine; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; zinc ion binding; metal ion binding; peptidase activity; aminopeptidase activity; hydrolase activity; metallopeptidase activity; metalloaminopeptidase activity;
Cellular component	integral component of membrane; membrane; apical part of cell; integral component of plasma membrane; lysosomal membrane; apical plasma membrane; brush border; extracellular exosome; cytoplasmic vesicle; external side of plasma membrane; plasma membrane; cytoplasm;
Biological process	cell-cell signaling; glomerulus development; proteolysis; angiogenesis; cell population proliferation; regulation of systemic arterial blood pressure by renin-angiotensin; cell migration; peptide catabolic process; angiotensin maturation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2028
	13809
	ENSG00000138792
	ENSMUSG00000028024
	Q07075
	P16406
	NM_001977
	NM_007934
	NP_001968; NP_001366540; NP_001366541; NP_001366542
	NP_031960
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamyl aminopeptidase (EC 3.4.11.7) is an enzyme that in humans is encoded by the ENPEP gene.

Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.^[5]

Alternative names

The enzyme has had a number of other names, including aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca²⁺-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, and angiotensinase A2. The human gene has also been designated CD249 (cluster of differentiation 249)

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138792 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028024 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C (2000). "Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure". Biochem. Soc. Trans. 28 (4): 435–40. doi:10.1042/0300-5127:0280435. PMID 10961935.

External links

The MEROPS online database for peptidases and their inhibitors: M01.003^{[dead link]}
Glutamyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138792 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10961935-5] Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C (2000). "Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure". Biochem. Soc. Trans. 28 (4): 435–40. doi:10.1042/0300-5127:0280435. PMID 10961935.

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[2]

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[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
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